Modification of CEA with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC vaccination
SG Kim, MY Park, CH Kim, HJ Sohn, HS Kim, JS Park… - Vaccine, 2008 - Elsevier
Carcinoembryonic antigen (CEA) is expressed on human colon carcinomas, is well
characterized, and continues to be a promising target for cancer immunotherapy in humans.
To enhance the immunogenecity of CEA, we developed a fusion gene (CRT-TAT-ΔCEA) of
the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid
of its signal sequences (ΔCEA) and evaluated anti-tumor immunity using RNA-pulsed
dendritic cell (DC) vaccination. Mice vaccinated with DC by electroporation with mRNA …
characterized, and continues to be a promising target for cancer immunotherapy in humans.
To enhance the immunogenecity of CEA, we developed a fusion gene (CRT-TAT-ΔCEA) of
the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid
of its signal sequences (ΔCEA) and evaluated anti-tumor immunity using RNA-pulsed
dendritic cell (DC) vaccination. Mice vaccinated with DC by electroporation with mRNA …
Modification of CEA with both CRT and TAT PTD induces potent anti-tumor immune responses in RNA-pulsed DC vaccination.
KSG Kim SungGuh, PMY Park MiYoung… - 2008 - cabidigitallibrary.org
Carcinoembryonic antigen (CEA) is expressed on human colon carcinomas, is well
characterized, and continues to be a promising target for cancer immunotherapy in humans.
To enhance the immunogenecity of CEA, we developed a fusion gene (CRT-TAT-ΔCEA) of
the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid
of its signal sequences (ΔCEA) and evaluated anti-tumor immunity using RNA-pulsed
dendritic cell (DC) vaccination. Mice vaccinated with DC by electroporation with mRNA …
characterized, and continues to be a promising target for cancer immunotherapy in humans.
To enhance the immunogenecity of CEA, we developed a fusion gene (CRT-TAT-ΔCEA) of
the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid
of its signal sequences (ΔCEA) and evaluated anti-tumor immunity using RNA-pulsed
dendritic cell (DC) vaccination. Mice vaccinated with DC by electroporation with mRNA …
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